Lab members

Welcome to the Genazzani lab

Welcome to the Genazzani lab. It was established in 2004 and is part of the Department of Pharmaceutical Sciences of the Università del Piemonte Orientale. The main lab is located in the "Alcoa" Building (, an architectural masterpiece by Renzo Piano, while the pharmacogenetics section is now located in a purpose-built laboratory in the "Wild" Building (, an example of urban re-conversion of industrial settings, as it used to be a cotton industry.

Historically, Armando Genazzani has focused its interests in basic mechanisms underlying calcium signalling, but in recent years a number of other research topics (for example, in the field of neuroscience and cancer biology) have also been pursued by the lab. In recent years, many lab members are devoting their efforts to the possibility that NAMPT, an enzyme involved in NAD synthesis, can be a pharmacological target in cancer. The lab is now starting to maintain a webpage on preclinical evidences that support the use of NAMPT inhibitors in cancer.

The lab also has strong ties with medicinal chemistry groups to pursue early drug discovery ( and with clinicians to understand individual differences in drug responses (

The lab always welcomes applications from talented undergraduates, graduates and post-doctoral fellows willing to join our efforts and ideas for collaborations, including multidisciplinary approaches.

Latest publications
TGF-beta2 and TGF-beta3 from cultured β-amyloid-treated or 3xTg-AD-derived astrocytes may mediate astrocyte-neuron communication.
Tapella L(1), Cerruti M(1), Biocotino I(1), Stevano A(1), Rocchio F(1), Canonico PL(1), Grilli M(1), Genazzani AA(1), Lim D(1).
Eur J Neurosci. 2018 Feb;47(3):211-221. doi: 10.1111/ejn.13819. Epub 2018 Jan 18.
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Susceptibility of different mouse strains to oxaliplatin peripheral neurotoxicity: Phenotypic and genotypic insights.
Marmiroli P(1), Riva B(2), Pozzi E(1), Ballarini E(1), Lim D(2), Chiorazzi A(1), Meregalli C(1), Distasi C(2), Renn CL(3), Semperboni S(1), Morosi L(4), Ruffinatti FA(2), Zucchetti M(4), Dorsey SG(3), Cavaletti G(1), Genazzani A(2), Carozzi VA(1).
PLoS One. 2017 Oct 11;12(10):e0186250. doi: 10.1371/journal.pone.0186250. eCollection 2017.
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Acetylcholine induces intracellular Ca2+ oscillations and nitric oxide release in mouse brain endothelial cells.
Zuccolo E(1), Lim D(2), Kheder DA(3), Perna A(4), Catarsi P(5), Botta L(1), Rosti V(5), Riboni L(6), Sancini G(7), Tanzi F(1), D'Angelo E(8), Guerra G(9), Moccia F(10).
Cell Calcium. 2017 Sep;66:33-47. doi: 10.1016/j.ceca.2017.06.003. Epub 2017 Jun 12.
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Chemotherapy-induced peripheral neurotoxicity: management informed by pharmacogenetics.
Argyriou AA(1), Bruna J(2)(3), Genazzani AA(4), Cavaletti G(5).
Nat Rev Neurol. 2017 Aug;13(8):492-504. doi: 10.1038/nrneurol.2017.88. Epub 2017 Jun 30.
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The prion protein regulates glutamate-mediated Ca2+ entry and mitochondrial Ca2+ accumulation in neurons.
De Mario A(1), Peggion C(1), Massimino ML(2), Viviani F(1), Castellani A(1), Giacomello M(3), Lim D(4), Bertoli A(5), Sorgato MC(5)(2).
J Cell Sci. 2017 Aug 15;130(16):2736-2746. doi: 10.1242/jcs.196972. Epub 2017 Jul 12.
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See complete list of pubblications

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