Lab members

121How did the Introduction of Biosimilar Filgrastim Influence the Prescribing Pattern of Granulocyte Colony-Stimulating Factors? Results from a Multicentre, Population-Based Study, from Five Italian Centres in the Years 2009-2014.
Marcian I(1), Ingrasciotta Y(1), Giorgianni F(1), Bolcato J(2), Chinellato A(2), Pirolo R(2), Di Giorgio A(3), Manna S(3), Ientile V(1), Gini R(4), Santarpia M(5), Genazzani AA(6), Uomo I(7), Pastorello M(7), Pollina Addario SW(8), Scondotto S(8), Cananzi P(9), Da Cas R(10), Traversa G(10), Rossi M(11), Sottosanti L(12), Caputi AP(1,)(13), Trifir G(14,)(15).
BioDrugs. 2016 May 2. [Epub ahead of print]
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120Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice.
Vicidomini C(1), Ponzoni L(2), Lim D(3), Schmeisser MJ(4,)(5), Reim D(4), Morello N(6), Orellana D(1), Tozzi A(7), Durante V(8), Scalmani P(9), Mantegazza M(10), Genazzani AA(3), Giustetto M(5), Sala M(1), Calabresi P(8), Boeckers TM(4), Sala C(1), Verpelli C(1).
Mol Psychiatry. 2016 Mar 29. doi: 10.1038/mp.2016.30. [Epub ahead of print]
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119Extracellular Nicotinamide Phosphoribosyltrasferase (eNAMPT), A New Cancer Metabokine.
Grolla AA(1), Travelli C(1), Genazzani AA(1), Sethi JK(1).
Br J Pharmacol. 2016 Apr 29. doi: 10.1111/bph.13505. [Epub ahead of print]
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118Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus.
Dinamarca MC(1), Guzzetti F(1), Karpova A(2), Lim D(3), Mitro N(1), Musardo S(1), Mellone M(1), Marcello E(1), Stanic J(1), Samaddar T(1), Burguire A(4), Caldarelli A(3), Genazzani AA(3), Perroy J(4), Fagni L(4), Canonico PL(3), Kreutz MR(2), Gardoni F(1), Luca MD(1).
Elife. 2016 Mar 15;5. pii: e12430. doi: 10.7554/eLife.12430.
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117Common European Mitochondrial Haplogroups in the Risk for Radiation-induced Subcutaneous Fibrosis in Breast Cancer Patients.
Terrazzino S(1), Deantonio L(2), Cargnin S(1), Donis L(3), Pisani C(3), Masini L(3), Gambaro G(3), Canonico PL(1), Genazzani AA(1), Krengli M(4).
Clin Oncol (R Coll Radiol). 2016 Mar 9. pii: S0936-6555(16)00084-4. doi: 10.1016/j.clon.2016.02.007. [Epub ahead of print]
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116Generation and usage of aequorin lentiviral vectors for Ca(2+) measurement in sub-cellular compartments of hard-to-transfect cells.
Lim D(1), Bertoli A(2), Sorgato MC(2), Moccia F(3).
Cell Calcium. 2016 Mar 10. pii: S0143-4160(16)30019-7. doi: 10.1016/j.ceca.2016.03.001.
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115Endoplasmic Reticulum Ca(2+) Handling and Apoptotic Resistance in Tumor-Derived Endothelial Colony Forming Cells.
Poletto V(1), Dragoni S(2), Lim D(3), Biggiogera M(4), Aronica A(1), Cinelli M(5), De Luca A(6), Rosti V(1), Porta C(7), Guerra G(8), Moccia F(2).
J Cell Biochem. 2016 Feb 24. doi: 10.1002/jcb.25524. [Epub ahead of print]
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114Triazole-curcuminoids: A new class of derivatives for 'tuning' curcumin bioactivities?
Caprioglio D(1), Torretta S(1), Ferrari M(1), Travelli C(1), Grolla AA(1), Condorelli F(1), Genazzani AA(2), Minassi A(3).
Bioorg Med Chem. 2016 Jan 15;24(2):140-52. doi: 10.1016/j.bmc.2015.11.044. Epub 2015 Nov 30.
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113Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD-95 complex.
Stanic J(1), Carta M(2), Eberini I(1), Pelucchi S(1), Marcello E(1), Genazzani AA(3), Racca C(4), Mulle C(2), Di Luca M(1), Gardoni F(1).
Nat Commun. 2015 Dec 18;6:10181. doi: 10.1038/ncomms10181.
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112The prion protein constitutively controls neuronal store-operated Ca(2+) entry through Fyn kinase.
De Mario A(1), Castellani A(1), Peggion C(1), Massimino ML(2), Lim D(3), Hill AF(4), Sorgato MC(5), Bertoli A(1).
Front Cell Neurosci. 2015 Oct 28;9:416.
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111Calcium signalling toolkits in astrocytes and spatio-temporal progression of Alzheimer's disease.
Lim D, Rodrguez-Arellano JJ, Parpura V, Zorec R, Zeidn-Chuli F, Genazzani AA, Verkhratsky A(1).
Curr Alzheimer Res. 2015 Nov 16. [Epub ahead of print]
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110The Role of TCF7L2 rs7903146 in Diabetes After Kidney Transplant: Results From a Single-Center Cohort and Meta-Analysis of the Literature.
Quaglia M(1), Terrazzino S, Musetti C, Cargnin S, Merlotti G, Cena T, Stratta P, Genazzani A.
Transplantation. 2015 Nov 21. [Epub ahead of print]
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109Calcium-related Neurotoxicity of Oxaliplatin: Understanding the Mechanisms to Drive Therapy.
Marmiroli P(1), Cavaletti G, Carozzi V, Riva B, Lim D, Genazzani AA.
Curr Med Chem. 2015 Oct 1. [Epub ahead of print]
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108Nicotinamide phosphoribosyltransferase (NAMPT/PBEF/visfatin) is a tumoural cytokine released from melanoma.
Grolla AA(1), Torretta S(1), Gnemmi I(1), Amoruso A(1), Orsomando G(2), Gatti M(1), Caldarelli A(1), Lim D(1), Penengo L(1,)(3), Brunelleschi S(1), Genazzani AA(1), Travelli C(1).
Pigment Cell Melanoma Res. 2015 Sep 10. doi: 10.1111/pcmr.12420.
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107How Much Are Biosimilars Used in Clinical Practice? A Retrospective Italian Population-Based Study of Erythropoiesis-Stimulating Agents in the Years 2009-2013.
Ingrasciotta Y(1), Giorgianni F, Bolcato J, Chinellato A, Pirolo R, Tari DU, Troncone C, Fontana A, Ientile V, Gini R, Santoro D, Santarpia M, Genazzani A, Uomo I, Pastorello M, Addario WS, Scondotto S, Cananzi P, Caputi AP, Trifir G.
BioDrugs. 2015 Aug;29(4):275-84. doi: 10.1007/s40259-015-0132-7.
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106Design, synthesis, and biological evaluation of combretabenzodiazepines: a novel class of anti-tubulin agents.
Galli U(1), Travelli C, Aprile S, Arrigoni E, Torretta S, Grosa G, Massarotti A, Sorba G, Canonico PL, Genazzani AA, Tron GC.
J Med Chem. 2015 Feb 12;58(3):1345-57. doi: 10.1021/jm5016389.
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105A novel Ca(2+)-mediated cross-talk between endoplasmic reticulum and acidic organelles: Implications for NAADP-dependent Ca(2+) signalling.
Ronco V(1), Potenza DM(2), Denti F(2), Vullo S(2), Gagliano G(2), Tognolina M(3), Guerra G(4), Pinton P(5), Genazzani AA(1), Mapelli L(6), Lim D(7), Moccia F(8).
Cell Calcium. 2015 Feb;57(2):89-100. doi: 10.1016/j.ceca.2015.01.001.
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104Combined effect of common gene variants on response to drug withdrawal therapy in medication overuse headache.
Cargnin S(1), Viana M, Sances G, Bianchi M, Ghiotto N, Tassorelli C, Nappi G, Canonico PL, Genazzani AA, Terrazzino S.
Eur J Clin Pharmacol. 2014 Oct;70(10):1195-202. doi: 10.1007/s00228-014-1726-6. Epub 2014 Aug 7.
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103Zinc transporter-1 (ZNT-1): a novel NMDA receptor-binding protein at postsynaptic density.
Mellone M(1), Pelucchi S, Alberti L, Genazzani A, Di Luca M, Gardoni F.
J Neurochem. 2014 Oct 15. doi: 10.1111/jnc.12968.
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102Triptan use in Italy: Insights from administrative databases.
Da Cas R(1), Nigro A(2), Terrazzino S(3), Sances G(4), Viana M(4), Tassorelli C(4), Nappi G(4), Cargnin S(3), Pisterna A(2), Traversa G(1), Genazzani AA(5).
Cephalalgia. 2014 Sep 22. pii: 0333102414550419.
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101Metabotropic Glutamate Receptor 5 in Down's Syndrome Hippocampus During Development: Increased Expression in Astrocytes.
Iyer AM, van Scheppingen J, Milenkovic I, Anink JJ, Lim D, Genazzani AA, Adle-Biassette H, Kovacs GG, Aronica E(1).
Curr Alzheimer Res. 2014;11(7):694-705.
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100Glial Calcium Signalling in Alzheimer's Disease.
Lim D(1), Ronco V, Grolla AA, Verkhratsky A, Genazzani AA.
Rev Physiol Biochem Pharmacol. 2014 Jun 17. [Epub ahead of print]
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99Functional polymorphisms in COMT and SLC6A4 genes influence the prognosis of patients with medication overuse headache after withdrawal therapy.
Cargnin S(1), Viana M, Ghiotto N, Bianchi M, Sances G, Tassorelli C, Nappi G, Canonico PL, Genazzani AA, Terrazzino S.
Eur J Neurol. 2014 Jul;21(7):989-95. doi: 10.1111/ene.12424. Epub 2014 Mar 29.
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98Diagnostic accuracy of HLA-B*57:01 screening for the prediction of abacavir hypersensitivity and clinical utility of the test: a meta-analytic review.
Cargnin S(1), Jommi C, Canonico PL, Genazzani AA, Terrazzino S.
Pharmacogenomics. 2014 May;15(7):963-76. doi: 10.2217/pgs.14.52.
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97Differential deregulation of astrocytic calcium signalling by amyloid-b, TNFa, IL-1b and LPS.
Ronco V, Grolla AA, Glasnov TN, Canonico PL, Verkhratsky A, Genazzani AA, Lim D.
Cell Calcium. 2014 Apr;55(4):219-29.
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96Pharmacogenomics of episodic migraine: time has come for a step forward.
Viana M(1), Terrazzino S, Genazzani AA, Grieco GS, Cargnin S, Santorelli FM, Pierelli F, Tassorelli C, Nappi G, Di Lorenzo C.
Pharmacogenomics. 2014 Mar;15(4):541-9. doi: 10.2217/pgs.14.20.
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95DPYD IVS14+1G>A and 2846A>T genotyping for the prediction of severe fluoropyrimidine-related toxicity: a meta-analysis.
Terrazzino S(1), Cargnin S, Del Re M, Danesi R, Canonico PL, Genazzani AA.
Pharmacogenomics. 2013 Aug;14(11):1255-72. doi: 10.2217/pgs.13.116.
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94Voltage-gated sodium channel polymorphisms play a pivotal role in the development of oxaliplatin-induced peripheral neurotoxicity: Results from a prospective multicenter study.
Argyriou AA, Cavaletti G, Antonacopoulou A, Genazzani AA, Briani C, Bruna J, Terrazzino S, Velasco R, Alberti P, Campagnolo M, Lonardi S, Cortinovis D, Cazzaniga M, Santos C, Psaromyalou A, Angelopoulou A, Kalofonos HP.
Cancer. 2013 Jul 2. doi: 10.1002/cncr.28234.
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93Tropisetron attenuates amyloid-beta-induced inflammatory and apoptotic responses in rats.
Rahimian R, Fakhfouri G, Ejtemaei Mehr S, Ghia JE, Genazzani AA, Payandemehr B, Dehpour AR, Mousavizadeh K, Lim D.
Eur J Clin Invest. 2013 Jul 12. doi: 10.1111/eci.12141.
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92Differentiation of adipose-derived stem cells into Schwann cell phenotype induces expression of P2X receptors that control cell death.
Faroni A(1), Rothwell SW, Grolla AA, Terenghi G, Magnaghi V, Verkhratsky A.
Cell Death Dis. 2013 Jul 25;4:e743. doi: 10.1038/cddis.2013.268.
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91An Opposite-Direction Modulation of the COMT Val158Met Polymorphism on the Clinical Response to Intrathecal Morphine and Triptans.
Cargnin S, Magnani F, Viana M, Tassorelli C, Mittino D, Cantello R, Sances G, Nappi G, Canonico PL, Genazzani AA, Raffaeli W, Terrazzino S.
J Pain. 2013 Jun 14. pii: S1526-5900(13)00968-1. doi: 10.1016/j.jpain.2013.04.006. [Epub ahead of print]
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90Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids.
Caldarelli A, Penucchini E, Caprioglio D, Genazzani AA, Minassi A.
Bioorg Med Chem. 2013 Jun 13. pii: S0968-0896(13)00502-6. doi: 10.1016/j.bmc.2013.05.053.
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89Metabolic fate of combretastatin A-1: LC-DAD-MS/MS investigation and biological evaluation of its reactive metabolites.
Aprile S, Zaninetti R, Del Grosso E, Genazzani AA, Grosa G.
J Pharm Biomed Anal. 2013 May 5;78-79:233-42.
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88Amyloid-b and Alzheimers disease type pathology differentially affects calcium signalling toolkit in astrocytes from different brain regions.
Grolla AA, Sim JA, Lim D, Rodriguez JJ, Genazzani AA, Verkhratsky A.
Cell Death Dis. 2013 May 9;4:e623. doi: 10.1038/cddis.2013.145.
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87Amyloid beta deregulates astroglial mGluR5-mediated calcium signaling via calcineurin and NF-kB.
Lim D, Iyer A, Ronco V, Grolla A, Canonico PL, Aronica E, Genazzani AA.
Glia, 2013 Apr 25. doi: 10.1002/glia.22502.
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86Severe acute nephrotoxicity in a kidney transplant patient despite low tacrolimus levels: a possible interaction between donor and recipient genetic polymorphisms.
Quaglia M, Terrazzino S, Boldorini R, Stratta P, Genazzani AA.
J Clin Pharm Ther. 2013 Apr 9. doi: 10.1111/jcpt.12066.
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85Triptan nonresponders: Do they exist and who are they?
Viana M, Genazzani AA, Terrazzino S, Nappi G, Goadsby PJ.
Cephalalgia. 2013 Apr 5.
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84Abeta leads to Ca(2+) signaling alterations and transcriptional changes in glial cells.
Grolla AA, Fakhfouri G, Balzaretti G, Marcello E, Gardoni F, Canonico P, Diluca M, Genazzani AA, Lim D.
Neurobiol Aging. 2013 Feb;34(2):511-22.[Epub ahead of print 2012 Jun 4.]
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83A Concise Synthesis of Pyrazole Analogues of Combretastatin A1 as Potent Anti-Tubulin Agents.
Zaninetti R, Cortese SV, Aprile S, Massarotti A, Canonico PL, Sorba G, Grosa G, Genazzani AA, Pirali T.
ChemMedChem. 2013 Feb 21. doi: 10.1002/cmdc.201200561.
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82Nicotinamide phosphoribosyltransferase (NAMPT) is over-expressed in melanoma lesions.
Maldi E, Travelli C, Caldarelli A, Agazzone N, Cintura S, Galli U, Scatolini M, Ostano P, Miglino B, Chiorino G, Boldorini R, Genazzani A.
Pigment Cell Melanoma Res. 2012 Oct 10. doi: 10.1111/pcmr.12037.
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81Store-operated ca(2+) entry is remodelled and controls in vitro angiogenesis in endothelial progenitor cells isolated from tumoral patients.
Lodola F, Laforenza U, Bonetti E, Lim D, Dragoni S, Bottino C, Ong HL, Guerra G, Ganini C, Massa M, Manzoni M, Ambudkar IS, Genazzani AA, Rosti V, Pedrazzoli P, Tanzi F, Moccia F, Porta C.
PLoS One. 2012;7(9):e42541. doi: 10.1371/journal.pone.0042541. Epub 2012 Sep 25.
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80WIN55212-2 attenuates amyloid-beta-induced neuroinflammation in rats through activation of cannabinoid receptors and PPAR-gamma pathway.
Fakhfouri G, Ahmadiani A, Rahimian R, Grolla AA, Moradi F, Haeri A.
Neuropharmacology. 2012 Sep;63(4):653-66.
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79The effect of CYP3A5 6986A>G and ABCB1 3435C>T on tacrolimus dose-adjusted trough levels and acute rejection rates in renal transplant patients: a systematic review and meta-analysis.
Terrazzino S, Quaglia M, Stratta P, Canonico PL, Genazzani AA.
Pharmacogenet Genomics. 2012 Aug;22(8):642-5. doi: 10.1097/FPC.0b013e3283557c74.
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78The NAMPT inhibitor FK866 reverts the damage in spinal cord injury.
Esposito E, Impellizzeri D, Mazzon E, Fakhfouri G, Rahimian R, Travelli C, Tron GC, Genazzani AA, Cuzzocrea S.
J Neuroinflammation. 2012 Apr 10;9(1):66. [Epub ahead of print]
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77Calcium signaling in closely related protozoan groups (Alveolata): Non-parasitic ciliates (Paramecium, Tetrahymena) vs. parasitic Apicomplexa (Plasmodium, Toxoplasma).
Plattner H, Sehring IM, Mohamed IK, Miranda K, De Souza W, Billington R, Genazzani A, Ladenburger EM.
Cell Calcium. 2012 Mar 2. [Epub ahead of print]
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76Common variants of eNOS and XRCC1 genes may predict acute skin toxicity in breast cancer patients receiving radiotherapy after breast conserving surgery.
Terrazzino S, Mattina PL, Masini L, Caltavuturo T, Gambaro G, Canonico PL, Genazzani AA, Krengli M.
Radiother Oncol. 2012 Jan 14.
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75Identification of novel antitubulin agents by using a virtual screening approach based on a 7-point pharmacophore model of the tubulin colchi-site.
Massarotti A, Theeramunkong S, Mesenzani O, Caldarelli A, Genazzani AA, Tron GC.
Chem Biol Drug Des. 2011 Dec;78(6):913-22. doi: 10.1111/j.1747-0285.2011.01245.x. Epub 2011 Oct 31.
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74N-Arylbenzamides: extremely simple scaffolds for the development of novel estrogen receptor agonists.
Caldarelli A, Minazzi P, Canonico PL, Genazzani AA, Giovenzana GB.
J Enzyme Inhib Med Chem. 2011 Dec 14.
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73The interactions of age, sex, body mass index, genetics, and steroid weight-based doses on tacrolimus dosing requirement after adult kidney transplantation.
Stratta P, Quaglia M, Cena T, Antoniotti R, Fenoglio R, Menegotto A, Ferrante D, Genazzani A, Terrazzino S, Magnani C.
Eur J Clin Pharmacol. 2011 Nov 20.
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72Common Variants of GSTP1, GSTA1, and TGFβ1 are Associated with the Risk of Radiation-Induced Fibrosis in Breast Cancer Patients.
Terrazzino S, La Mattina P, Gambaro G, Masini L, Franco P, Canonico PL, Genazzani AA, Krengli M.
Int J Radiat Oncol Biol Phys. 2011 Nov 11.
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71Regioselective suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues.
Theeramunkong S, Caldarelli A, Massarotti A, Aprile S, Caprioglio D, Zaninetti R, Teruggi A, Pirali T, Grosa G, Tron GC, Genazzani AA.
J Med Chem. 2011 Jul 28;54(14):4977-86. Epub 2011 Jun 30.
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70Reciprocal potentiation of the antitumoral activities of FK866, an inhibitor of nicotinamide phosphoribosyltransferase, and etoposide or cisplatin in neuroblastoma cells.
Travelli C, Drago V, Maldi E, Kaludercic N, Galli U, Boldorini R, Di Lisa F, Tron GC, Canonico PL, Genazzani AA.
J Pharmacol Exp Ther. 2011 Jun 17.
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69NAADP links histamine H1 receptors to secretion of von Willebrand factor in human endothelial cells.
Esposito B, Gambara G, Lewis AM, Palombi F, D'Alessio A, Taylor LX, Genazzani AA, Ziparo E, Galione A, Churchill GC, Filippini A.
Blood. 2011 May 5;117(18):4968-77. Epub 2011 Mar 1.
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68Association of haplotype combination of serotonin transporter gene polymorphisms with monthly headache days in MOH patients.
Terrazzino S, Tassorelli C, Sances G, Allena M, Viana M, Monaco F, Bellomo G, Nappi G, Canonico PL, Genazzani AA.
Eur J Neurol. 2011 May 18.
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67Cellular prion protein is implicated in the regulation of local Ca2+ movements in cerebellar granule neurons.
Lazzari C, Peggion C, Stella R, Massimino ML, Lim D, Bertoli A, Sorgato MC.
J Neurochem. 2011 Mar;116(5):881-90. doi: 10.1111/j.1471-4159.2010.07015.x.
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66Activation of TRPV4 channels reduces migration of immortalized neuroendocrine cells.
Zaninetti R, Fornarelli A, Ciarletta M, Lim D, Caldarelli A, Pirali T, Cariboni A, Owsianik G, Nilius B, Canonico PL, Distasi C, Genazzani AA.
J Neurochem. 2011 Feb;116(4):606-15.
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65Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: Synthesis and biological evaluation.
Mesenzani O, Massarotti A, Giustiniano M, Pirali T, Bevilacqua V, Caldarelli A, Canonico P, Sorba G, Novellino E, Genazzani AA, Tron GC.
Bioorg Med Chem Lett. 2011 Jan 15;21(2):764-8. Epub 2010 Nov 28.
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64Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli.
Costa V, Giacomello M, Hudec R, Lopreiato R, Ermak G, Lim D, Malorni W, Davies KJ, Carafoli E, Scorrano L.
EMBO Mol Med. 2010 Dec;2(12):490-503. doi: 10.1002/emmm.201000102.
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63Role of 2 common variants of 5HT2A gene in medication overuse headache.
Terrazzino S, Sances G, Balsamo F, Viana M, Monaco F, Bellomo G, Martignoni E, Tassorelli C, Nappi G, Canonico PL, Genazzani AA.
Headache. 2010 Nov;50(10):1587-96. doi: 10.1111/j.1526-4610.2010.01757.x. Epub 2010 Aug 27.
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62Multiple roles of protein kinase a in arachidonic acid-mediated Ca2+ entry and tumor-derived human endothelial cell migration.
Fiorio Pla A, Genova T, Pupo E, Tomatis C, Genazzani A, Zaninetti R, Munaron L.
Mol Cancer Res. 2010 Nov;8(11):1466-76. Epub 2010 Sep 24.
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61The serotonin transporter gene polymorphism STin2 VNTR confers an increased risk of inconsistent response to triptans in migraine patients.
Terrazzino S, Viana M, Floriddia E, Monaco F, Mittino D, Sances G, Tassorelli C, Nappi G, Rinaldi M, Canonico PL, Genazzani AA.
Eur J Pharmacol. 2010 Sep 1;641(2-3):82-7. Epub 2010 May 18.
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60Novel adenosine and cAMP signalling pathways in migrating glial cells.
Bernascone S, Erriquez J, Ferraro M, Genazzani AA, Distasi C.
Cell Calcium. 2010 Jul;48(1):83-90. Epub 2010 Aug 4.
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59Synthesis, molecular docking and biological evaluation as HDAC inhibitors of cyclopeptide mimetics by a tandem three-component reaction and intramolecular [3+2] cycloaddition.
Pirali T, Faccio V, Mossetti R, Grolla AA, Di Micco S, Bifulco G, Genazzani AA, Tron GC.
Mol Divers. 2010 Feb;14(1):109-21. Epub 2009 May 28.
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58A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry.
Colombano G, Travelli C, Galli U, Caldarelli A, Chini MG, Canonico PL, Sorba G, Bifulco G, Tron GC, Genazzani AA.
J Med Chem. 2010 Jan 28;53(2):616-23.
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57Dasatinib: is it all in the dose?
Condorelli F, Genazzani AA.
BioDrugs. 2010 Jun;24(3):157-63.
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56Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylases.
Grolla AA, Podestà V, Chini MG, Di Micco S, Vallario A, Genazzani AA, Canonico PL, Bifulco G, Tron GC, Sorba G, Pirali T.
J Med Chem. 2009 May 14;52(9):2776-85.
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55Wld S protein requires Nmnat activity and a short N-terminal sequence to protect axons in mice.
Conforti L, Wilbrey A, Morreale G, Janeckova L, Beirowski B, Adalbert R, Mazzola F, Di Stefano M, Hartley R, Babetto E, Smith T, Gilley J, Billington RA, Genazzani AA, Ribchester RR, Magni G, Coleman M.
J Cell Biol. 2009 Feb 23;184(4):491-500.
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54Plasma membrane Calcium ATPase.
Carafoli E, Lim D.
In "Handbook of Neurochemistry andMolecular Neurobiology: Neural signaling mechanisms". Ed. Lajtha A., Volume Ed. Mikishiba K. 2009 Springer.
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53Characterization of NAD uptake in mammalian cells.
Billington RA, Travelli C, Ercolano E, Galli U, Roman CB, Grolla AA, Canonico PL, Condorelli F, Genazzani AA.
J Biol Chem. 2008 Mar 7;283(10):6367-74. Epub 2008 Jan 7.
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52A concise entry into nonsymmetrical alkyl polyamines.
Pirali T, Callipari G, Ercolano E, Genazzani AA, Giovenzana GB, Tron GC.
Org Lett. 2008 Oct 2;10(19):4199-202. Epub 2008 Sep 3.
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51The novel mouse mutation Oblivion inactivates the PMCA2 pump and causes progressive hearing loss.
Spiden SL, Bortolozzi M, Di Leva F, de Angelis MH, Fuchs H, Lim D, Ortolano S, Ingham NJ, Brini M, Carafoli E, Mammano F, Steel KP.
PLoS Genet. 2008 Oct;4(10):e1000238. doi: 10.1371/journal.pgen.1000238.
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50Interplay of the Ca2+-binding protein DREAM with presenilin in neuronal Ca2+ signaling.
Fedrizzi L, Lim D, Carafoli E, Brini M.
J Biol Chem. 2008 Oct 10;283(41):27494-503. doi: 10.1074/jbc.M804152200.
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49Triazole-modified histone deacetylase inhibitors as a rapid route to drug discovery.
Pirali T, Pagliai F, Mercurio C, Boggio R, Canonico PL, Sorba G, Tron GC, Genazzani AA.
J Comb Chem. 2008 Sep-Oct;10(5):624-7. Epub 2008 Jul 4.
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48Solution-phase parallel synthesis and biological evaluation of combretatriazoles.
Cafici L, Pirali T, Condorelli F, Del Grosso E, Massarotti A, Sorba G, Canonico PL, Tron GC, Genazzani AA.
J Comb Chem. 2008 Sep-Oct;10(5):732-40. Epub 2008 Aug 6.
[Show abstract ]  
47NAADP-induced Ca(2+ signaling in response to endothelin is via the receptor subtype B and requires the integrity of lipid rafts/caveolae.
Gambara G, Billington RA, Debidda M, D'Alessio A, Palombi F, Ziparo E, Genazzani AA, Filippini A.
J Cell Physiol. 2008 Aug;216(2):396-404.
[Show abstract ]  
46The plasma membrane Ca2+ ATPase of animal cells: structure, function and regulation.
Di Leva F, Domi T, Fedrizzi L, Lim D, Carafoli E.
Arch Biochem Biophys. 2008 Aug 1;476(1):65-74. doi: 10.1016/
[Show abstract ]  
45Synthesis and biological evaluation of isosteric analogues of FK866, an inhibitor of NAD salvage.
Galli U, Ercolano E, Carraro L, Blasi Roman CR, Sorba G, Canonico PL, Genazzani AA, Tron GC, Billington RA.
ChemMedChem. 2008 May;3(5):771-9.
[Show abstract ]  
44Calcium and signal transduction.
Fedrizzi L, Lim D, Carafoli E.
Biochem Mol Biol Educ. 2008 May;36(3):175-80. doi: 10.1002/bmb.20187.
[Show abstract ]  
43NAD depletion by FK866 induces autophagy.
Billington RA, Genazzani AA, Travelli C, Condorelli F.
Autophagy. 2008 Apr;4(3):385-7. Epub 2008 Jan 23.
[Show abstract ]  
42Gene regulation in the frontal cortex of rats exposed to the chronic mild stress paradigm, an animal model of human depression.
Orsetti M, Di Brisco F, Canonico PL, Genazzani AA, Ghi P.
Eur J Neurosci. 2008 Apr;27(8):2156-64. Epub 2008 Mar 25.
[Show abstract ]  
41Click chemistry reactions in medicinal chemistry: applications of the 1,3-dipolar cycloaddition between azides and alkynes.
Tron GC, Pirali T, Billington RA, Canonico PL, Sorba G, Genazzani AA.
Med Res Rev. 2008 Mar;28(2):278-308.
[Show abstract ]  
40Calcineurin primes immature gonadotropin-releasing hormone-secreting neuroendocrine cells for migration.
Zaninetti R, Tacchi S, Erriquez J, Distasi C, Maggi R, Cariboni A, Condorelli F, Canonico PL, Genazzani AA.
Mol Endocrinol. 2008 Mar;22(3):729-36. Epub 2007 Nov 21.
[Show abstract ]  
39Pharmacokinetic and pharmacodynamic features of palonosetron.
Genazzani AA, Billington RA.
Tumori. 2008 Mar-Apr;94(2):suppl 6-13.
[Show abstract ]  
385-hydroxytryptamine1B receptor and triptan response in migraine, lack of association with common polymorphisms.
Velati D, Viana M, Cresta S, Mantegazza P, Testa L, Bettucci D, Rinaldi M, Sances G, Tassorelli C, Nappi G, Canonico PL, Martignoni E, Genazzani AA.
Eur J Pharmacol. 2008 Feb 2;580(1-2):43-7. Epub 2007 Oct 30.
[Show abstract ]  
37Inhibitors of histone deacetylase (HDAC) restore the p53 pathway in neuroblastoma cells.
Condorelli F, Gnemmi I, Vallario A, Genazzani AA, Canonico PL.
Br J Pharmacol. 2008 Feb;153(4):657-68. Epub 2007 Dec 3.
[Show abstract ]  
36Calcium homeostasis and mitochondrial dysfunction in striatal neurons of Huntington disease.
Lim D, Fedrizzi L, Tartari M, Zuccato C, Cattaneo E, Brini M, Carafoli E.
J Biol Chem. 2008 Feb 29;283(9):5780-9.
[Show abstract ]  
35Difficulties in the production of identical drug products from a pharmaceutical technology viewpoint.
Genazzani AA, Pattarino F.
Drugs R D. 2008;9(2):65-72.
[Show abstract ]  
34Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry.
Imperio D, Pirali T, Galli U, Pagliai F, Cafici L, Canonico PL, Sorba G, Genazzani AA, Tron GC.
Bioorg Med Chem. 2007 Nov 1;15(21):6748-57. Epub 2007 Aug 22.
[Show abstract ]  
33Plasma-membrane calcium pumps and hereditary deafness.
Brini M, Di Leva F, Domi T, Fedrizzi L, Lim D, Carafoli E.
Biochem Soc Trans. 2007 Nov;35(Pt 5):913-8.
[Show abstract ]  
32CD38/CD19: a lipid raft-dependent signaling complex in human B cells.
Deaglio S, Vaisitti T, Billington R, Bergui L, Omede' P, Genazzani AA, Malavasi F.
Blood. 2007 Jun 15;109(12):5390-8. Epub 2007 Feb 27.
[Show abstract ]  
31PPADS is a reversible competitive antagonist of the NAADP receptor.
Billington RA, Genazzani AA.
Cell Calcium. 2007 Jun;41(6):505-11. Epub 2006 Nov 7.
[Show abstract ]  
30Estrogenic analogues synthesized by click chemistry.
Pirali T, Gatti S, Di Brisco R, Tacchi S, Zaninetti R, Brunelli E, Massarotti A, Sorba G, Canonico PL, Moro L, Genazzani AA, Tron GC, Billington RA.
ChemMedChem. 2007 Apr;2(4):437-40.
[Show abstract ]  
29A functional study of plasma-membrane calcium-pump isoform 2 mutants causing digenic deafness.
Ficarella R, Di Leva F, Bortolozzi M, Ortolano S, Donaudy F, Petrillo M, Melchionda S, Lelli A, Domi T, Fedrizzi L, Lim D, Shull GE, Gasparini P, Brini M, Mammano F, Carafoli E.
Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1516-21.
[Show abstract ]  
28Biosimilar drugs : concerns and opportunities.
Genazzani AA, Biggio G, Caputi AP, Del Tacca M, Drago F, Fantozzi R, Canonico PL.
BioDrugs. 2007;21(6):351-6.
[Show abstract ]  
27Emerging functions of extracellular pyridine nucleotides.
Billington RA, Bruzzone S, De Flora A, Genazzani AA, Koch-Nolte F, Ziegler M, Zocchi E.
Mol Med. 2006 Nov-Dec;12(11-12):324-7.
[Show abstract ]  
26Characterization of cyclic adenine dinucleotide phosphate ribose levels in human spermatozoa.
Billington RA, Harper C, Bellomo EA, Publicover S, Barratt CL, Genazzani AA.
Fertil Steril. 2006 Oct;86(4):891-8. Epub 2006 Aug 9.
[Show abstract ]  
25Pharmacological characterization of NAADP-induced Ca2+ signals in starfish oocytes.
Moccia F, Billington RA, Santella L.
Biochem Biophys Res Commun. 2006 Sep 22;348(2):329-36. Epub 2006 Jun 5.
[Show abstract ]  
24Modulation of calcium signalling by the actin-binding protein cofilin.
Nusco GA, Chun JT, Ercolano E, Lim D, Gragnaniello G, Kyozuka K, Santella L.
Biochem Biophys Res Commun. 2006 Sep 15;348(1):109-14.
[Show abstract ]  
23Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents.
Pirali T, Busacca S, Beltrami L, Imovilli D, Pagliai F, Miglio G, Massarotti A, Verotta L, Tron GC, Sorba G, Genazzani AA.
J Med Chem. 2006 Aug 24;49(17):5372-6.
[Show abstract ]  
22Medicinal chemistry of combretastatin A4: present and future directions.
Tron GC, Pirali T, Sorba G, Pagliai F, Busacca S, Genazzani AA.
J Med Chem. 2006 Jun 1;49(11):3033-44.
[Show abstract ]  
21A transport mechanism for NAADP in a rat basophilic cell line.
Billington RA, Bellomo EA, Floriddia EM, Erriquez J, Distasi C, Genazzani AA.
FASEB J. 2006 Mar;20(3):521-3. Epub 2006 Jan 10.
[Show abstract ]  
20Rapid synthesis of triazole-modified resveratrol analogues via click chemistry.
Pagliai F, Pirali T, Del Grosso E, Di Brisco R, Tron GC, Sorba G, Genazzani AA.
J Med Chem. 2006 Jan 26;49(2):467-70.
[Show abstract ]  
19NAADP and InsP3 play distinct roles at fertilization in starfish oocytes.
Moccia F, Nusco GA, Lim D, Kyozuka K, Santella L.
Dev Biol. 2006 Jun 1;294(1):24-38.
[Show abstract ]  
18Sphingosine releases Ca2+ from intracellular stores via the ryanodine receptor in sea urchin egg homogenates.
Floriddia EM, Pace D, Genazzani AA, Canonico PL, Condorelli F, Billington RA.
Biochem Biophys Res Commun. 2005 Dec 23;338(3):1316-21. Epub 2005 Oct 25.
[Show abstract ]  
17Somatostatin and the somatostatin receptor 2 are reciprocally controlled by calcineurin during cerebellar granule cell maturation.
Kramer D, Caruso A, Nicoletti F, Genazzani AA.
J Neurochem. 2005 Sep;94(5):1374-83. Epub 2005 Jul 5.
[Show abstract ]  
16Synthesis and biological activity of mustard derivatives of combretastatins.
Coggiola B, Pagliai F, Allegrone G, Genazzani AA, Tron GC.
Bioorg Med Chem Lett. 2005 Aug 1;15(15):3551-4.
[Show abstract ]  
15SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis.
Appendino G, Prosperini S, Valdivia C, Ballero M, Colombano G, Billington RA, Genazzani AA, Sterner O.
J Nat Prod. 2005 Aug;68(8):1213-7.
[Show abstract ]  
14Role of the nicotinic acid group in NAADP receptor selectivity.
Billington RA, Tron GC, Reichenbach S, Sorba G, Genazzani AA.
Cell Calcium. 2005 Jan;37(1):81-6.
[Show abstract ]  
13Synthesis and cytotoxic evaluation of combretafurazans.
Tron GC, Pagliai F, Del Grosso E, Genazzani AA, Sorba G.
J Med Chem. 2005 May 5;48(9):3260-8.
[Show abstract ]  
12NAADP triggers the fertilization potential in starfish oocytes.
Moccia F, Lim D, Kyozuka K, Santella L.
Cell Calcium. 2004 Dec;36(6):515-24.
[Show abstract ]  
11Triazine dyes are agonists of the NAADP receptor.
Billington RA, Bak J, Martinez-Coscolla A, Debidda M, Genazzani AA.
Br J Pharmacol. 2004 Aug;142(8):1241-6. Epub 2004 Jul 20.
[Show abstract ]  
10Calcium and fertilization: the beginning of life.
Santella L, Lim D, Moccia F.
Trends Biochem Sci. 2004 Aug;29(8):400-8.
[Show abstract ]  
9Production and characterization of reduced NAADP (nicotinic acid-adenine dinucleotide phosphate).
Billington RA, Thuring JW, Conway SJ, Packman L, Holmes AB, Genazzani AA.
Biochem J. 2004 Feb 15;378(Pt 1):275-80.
[Show abstract ]  
8NAADP activates a Ca2+ current that is dependent on F-actin cytoskeleton.
Moccia F, Lim D, Nusco GA, Ercolano E, Santella L.
FASEB J. 2003 Oct;17(13):1907-9.
[Show abstract ]  
7The M-phase-promoting factor modulates the sensitivity of the Ca2+ stores to inositol 1,4,5-trisphosphate via the actin cytoskeleton.
Lim D, Ercolano E, Kyozuka K, Nusco GA, Moccia F, Lange K, Santella L.
J Biol Chem. 2003 Oct 24;278(43):42505-14.
[Show abstract ]  
6Ca2+ signalling and membrane current activated by cADPr in starfish oocytes.
Moccia F, Nusco GA, Lim D, Ercolano E, Gragnaniello G, Brown ER, Santella L.
Pflugers Arch. 2003 Aug;446(5):541-52.
[Show abstract ]  
5Activated M-phase-promoting factor (MPF) is exported from the nucleus of starfish oocytes to increase the sensitivity of the Ins(1,4,5)P3 receptors.
Santella L, Ercolano E, Lim D, Nusco GA, Moccia F.
Biochem Soc Trans. 2003 Feb;31(Pt 1):79-82.
[Show abstract ]  
4Role of the actin cytoskeleton in store-mediated calcium entry in glioma C6 cells.
Sabała P, Targos B, Caravelli A, Czajkowski R, Lim D, Gragnaniello G, Santella L, Barańska J.
Biochem Biophys Res Commun. 2002 Aug 16;296(2):484-91.
[Show abstract ]  
3Activation of oocytes by latrunculin A.
Lim D, Lange K, Santella L.
FASEB J. 2002 Jul;16(9):1050-6.
[Show abstract ]  
2Calcium and calcium-linked second messengers are main actors in the maturation and fertilization of starfish oocytes.
Santella L, Nusco GA, Lim D.
In "Cyclic ADP-ribose and NAADP. Structures, metabolism and function". Edt. by Lee HC. Kluwer Academic Publishers,2002.
[Show abstract ]  
1NAADP+ initiates the Ca2+ response during fertilization of starfish oocytes.
Lim D, Kyozuka K, Gragnaniello G, Carafoli E, Santella L.
FASEB J. 2001 Oct;15(12):2257-67.
[Show abstract ]  

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