From september 2012- Researcher fixed-term (Scientific Sector: BIO/14), Department of Pharmaceutical Sciences at the Università del Piemonte Orientale “A. Avogadro”, Novara, Italy.
Main research areas of interest:
- Pharmacogenetics of migraine: identification of genetic polymorphisms as predictive factors for response to triptans in migraine patients, and for migrain progression to Medication Overuse Headache (MOH). Affecting up to 12% of males and 24% of females in the general population, migraine is a primary headache disorder with a profound social and economic impact. The term “medication-overuse headache” has been recently introduced to describe a chronic daily headache usually occurring in people with migraine or tension-type headaches caused by an excessive use of medication taken for symptomatic headache relief.
- Radiogenetics in breast cancer: identification of genetic polymorphisms as predictors for acute and late normal tissue toxicity in patients submitted to post-surgical radiotherapy for breast cancer. The identification of relevant gene variants could contribute to the construction of predictive risk models for the occurrence of radiation-induced toxicities in breast cancer patients.
- Pharmacogenetics of transplantation: evaluation of the role of genetic variants as predictors of clinical outcome, pharmacokinetics and adverse effects of immunosuppressive drugs in kidney transplant patients. The results of the ongoing pharmacogenetic studies should provide a basis towards the personalization of immunosuppressive drug therapy.
- Validation of pharmacogenetic markers: conduction of meta-analyses on published data to quantitatively evaluate the impact of genetic variants in response to specific pharmacological treatments. The identification of genetic determinants with proven clinical value should provide the basis for the use of pharmacogenetic testing in clinical practice as tool to improve the safety and efficacy of pharmacological treatments.
1990 - Degree in Biology Sciences, State University of Milan (Italy).
1995 - Ph.D in Pharmacology, obtained at "Mario Negri" Research Institute, Milan.
2006 – Advanced Training in “Nutrition and Wellness”, State University of Milan.
2008 – 2012: Post-doctoral position at the Department of Chemical, Food, Pharmaceutical and Pharmacological Sciences (DiSCAFF), Università del Piemonte Orientale.
1999 – 2006: Senior Scientist at Research and Innovation, a private biotech company of Northeast Italy focusing on "Pharmacogenetics" and " in vivo Pharmacology ".
1996-1999: Post-doctoral position at the INSERM UNIT 334 (Orsay, France), funded by Biomed grant "Training and Mobility of Researchers", contract n: BMH4-CT96-5007.
1992- 1996: Fellowship at “Mario Negri Institute for Pharmacological Research”, Milan.