Role of calcineurin in glial cells in health and disease
Calcineurin is a Ca2+/CaM dependent phosphatase that senses activity and decodes cellular messages. It is a ubiquitous enzyme and is the target of some of the most important immunosuppressants, tacrolimus and cyclosporin. While it is abundantly expressed in neurons, we have found that also glial cells express this protein. We are interested in understanding its role in norma lastroglial physiology as well as in disorders such as Alzheimer’s disease and epilepsy.
This work has been founded by PRIN (Grant PRIN-2015N4FKJ4), Cariplo Foundation (Grants 2008-2319, 2013-0795, 2014-1094)
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